Last season City made it to the Northern Arena Final, where they lost 3-2 on aggregate to eventual winners Crewe Alexandra, with the first leg at The Ricoh Arena setting a new JPT attendance record.
Coventry City have already faced Orient in cup competition this season, losing 3-2 at The Matchroom Stadium in the First Round of the League Cup in a game which saw Carl Baker sent off and Leon Clarke miss a penalty.
The date for this game has been confirmed as Tuesday, October 8th with kick off at 7:30pm.
Full second round draw
Southend United v Dagenham and Redbridge
Peterborough United v Brentford
Stevenage v Milton Keynes Dons
Leyton Orient v Coventry City
Oxford United v Portsmouth
Swindon Town v Plymouth Argyle
Wycombe Wanderers v Bristol City
Crawley Town v Newport County
York City v Rotherham United
Sheffield United v Hartlepool United
Wolverhampton Wanderers v Notts County
Mansfield Town v Chesterfield
Fleetwood Town v Crewe Alexandra
Morecambe v Carlisle United
Preston North End v Oldham Athletic
Port Vale v Rochdale
- Ties to be played in the week beginning October 7.